The decisive role of fumarase: Responsive signaling to glucose deficiency.

Yu, Qiujing; Wang, Ting; Jiang, Yuhui

Yu, Qiujing; Wang, Ting; Jiang, Yuhui.

Afiliación

Yu Q; The Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Wang T; The Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Jiang Y; The Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.

Mol Cell Oncol ; 5(4): e1363848, 2018.

Article en En | MEDLINE | ID: mdl-30250906

RESUMEN

Our recent study shows that AMPK normally phosphorates fumarase (FH) at Ser75 under glucose deprivation, resulting in FH-ATF2 complex formation that facilitates transcription for cell growth arrest. Meanwhile, O-GlcNAc transferase can compete with AMPK to O-GlcNAcylate FH. In tumor cells, FH is highly O-GlcNAcylated and is proinhibited from AMPK-ATF2 signaling.

Palabras clave

AMPK; O-GlcNAc transferase; fumarase; glucose deficiency

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Cell Oncol Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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