Dysfunction of Neuromuscular Synapses in the Genetic Model of Alzheimer's Disease.
Bull Exp Biol Med
; 165(5): 669-673, 2018 Sep.
Article
en En
| MEDLINE
| ID: mdl-30255242
ABSTRACT
The function of synaptic transmission and presynaptic vesicular cycle in the neuromuscular synapses of the diaphragm was studied in transgenic APP/PS1 mice (Alzheimer's disease model). The decrease in the quantal content of end-plate potential, intense depression of the amplitude of terminal plate potentials under conditions of lasting high frequency stimulation (50 Hz), a drastic prolongation of the synaptic vesicle recycling time in APP/PS1 mice in comparison with wild type mice were detected. Manifest dysfunction of the neuromuscular synapses, caused by disordered neurosecretion and recycling of the synaptic vesicles in the presynaptic nerve endings, was detected in the Alzheimer's disease model on transgenic APP/PS1 mice. The study supplemented the notions on the pathogenesis of Alzheimer's disease as a systemic disease, while the detected phenomena could just partially explain the development of motor disorders in this disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vesículas Sinápticas
/
Terminales Presinápticos
/
Transmisión Sináptica
/
Enfermedad de Alzheimer
/
Placa Motora
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2018
Tipo del documento:
Article
País de afiliación:
Rusia