Antimitochondrial Antibody-Negative Primary Biliary Cholangitis: Is It Really the Same Disease?
Clin Liver Dis
; 22(3): 589-601, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-30259855
ABSTRACT
Antimitochondrial antibody (AMA)-negative primary biliary cholangitis (PBC) is a term reserved for patients with clinical and histopathological findings consistent with PBC but without positive AMA. There does not seem to be a natural progression from AMA negativity to positivity. Antinuclear and antismooth muscle antibodies are frequently found in the absence of histologic autoimmune hepatitis features. The disease course may be more severe than AMA-positive. Response to standard therapy for PBC and autoimmune hepatitis varies. Nevertheless, there is insufficient evidence to suggest AMA-negative PBC is different enough to warrant classification as a separate disease from AMA-positive PBC.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Cirrosis Hepática Biliar
/
Mitocondrias
Límite:
Humans
Idioma:
En
Revista:
Clin Liver Dis
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos