Ubiquitination at the interface of tumor viruses and DNA damage responses.
Curr Opin Virol
; 32: 40-47, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-30261451
ABSTRACT
Viruses exploit cellular ubiquitination machinery to shape the host proteome and promote productive infection. Among the cellular processes influenced by viral manipulation of ubiquitination is the DNA damage response (DDR), a network of cellular signaling pathways that sense and respond to genomic damage. This host-pathogen interaction is particularly important during virus replication and transformation by DNA tumor viruses. Manipulating DDR pathways can promote virus replication but also impacts host genomic instability, potentially leading to cellular transformation and tumor formation. We review ways in which viruses are known to hijack the cellular ubiquitin system to reshape host DDR pathways.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus Oncogénicos
/
Infecciones Tumorales por Virus
/
Daño del ADN
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Interacciones Huésped-Patógeno
/
Ubiquitinación
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Virol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos