Dynamic ERK signaling regulation in intestinal tumorigenesis.
Mol Cell Oncol
; 5(5): e1506684, 2018.
Article
en En
| MEDLINE
| ID: mdl-30263947
ABSTRACT
Extracellular signal-regulated kinase (ERK) plays a critical role in tissue homeostasis and tumorigenesis. By utilizing live imaging approaches, we recently uncovered ERK activity dynamics in the intestinal epithelium. Notably, we showed that ERK activity dynamics are defined by composite regulation from two distinct upstream receptors, and alteration of their functional balance underlies tumor cell-specific traits. Here, we discuss these findings.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Mol Cell Oncol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Japón