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Vascular calcification in patients with large-vessel vasculitis compared to patients with hyperlipidemia.
Banerjee, Shubhasree; Bagheri, Mohammadhadi; Sandfort, Veit; Ahlman, Mark A; Malayeri, Ashkan A; Bluemke, David A; Yao, Jianhua; Grayson, Peter C.
Afiliación
  • Banerjee S; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 10 Center Drive, Building 10, Rm 216G, Bethesda, MD 20892, USA.
  • Bagheri M; Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive Building 10, Bethesda, MD 20892, USA.
  • Sandfort V; Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive Building 10, Bethesda, MD 20892, USA.
  • Ahlman MA; Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive Building 10, Bethesda, MD 20892, USA.
  • Malayeri AA; Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive Building 10, Bethesda, MD 20892, USA.
  • Bluemke DA; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison WI, USA.
  • Yao J; Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive Building 10, Bethesda, MD 20892, USA.
  • Grayson PC; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 10 Center Drive, Building 10, Rm 216G, Bethesda, MD 20892, USA. Electronic address: peter.grayson@nih.gov.
Semin Arthritis Rheum ; 48(6): 1068-1073, 2019 06.
Article en En | MEDLINE | ID: mdl-30318124
OBJECTIVE: Calcification of the coronary arteries, aorta, and branch vessels can occur in both large-vessel vasculitis (LVV) and atherosclerosis. The study objective was to determine the location and amount of vascular calcification in patients with LVV versus hyperlipidemia (HLD) and to identify risk factors associated with vascular calcification in LVV. METHODS: Patients with giant cell arteritis (GCA), Takayasu's arteritis (TAK), and HLD underwent non-contrast computed tomography of the aorta and branch vessels. Vascular calcification in 14 specific arterial territories (4 segments of the aorta, 9 branch arteries, and the coronary arteries) was quantified throughout the large arteries by a cumulative Agatston score. Multivariate linear regression analyses were used to identify associations between traditional and disease-specific risk factors and total Agatston score. RESULTS: A total of 88 subjects, including GCA (n = 29); TAK (n = 22); and HLD (n = 37), participated. Prevalence of vascular calcification in the aorta and branch vessels significantly differed in the coronary arteries (HLD = 67%, GCA = 35%, TAK = 9%, p < 0.01). Total Agatston scores were higher in GCA (median 3260, range 25-18,138) versus HLD (460, 19-17,215) (p < 0.01) but did not significantly differ between GCA and TAK (1944, 52-47,520) (p = 0.53). In multivariable regression analysis, age, type of vasculitis, and prednisone use was associated with vascular calcification in LVV. CONCLUSION: The prevalence of coronary artery calcification is lower in LVV compared to HLD, but the amount of total vascular calcification throughout the large arteries is greater in LVV. Both traditional and disease-specific risk factors are associated with vascular calcification in LVV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arteritis de Células Gigantes / Arteritis de Takayasu / Aterosclerosis / Calcificación Vascular / Hiperlipidemias Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Semin Arthritis Rheum Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arteritis de Células Gigantes / Arteritis de Takayasu / Aterosclerosis / Calcificación Vascular / Hiperlipidemias Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Semin Arthritis Rheum Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos