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Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop.
Misra, Maneesh K; Augusto, Danillo G; Martin, Gonzalo Montero; Nemat-Gorgani, Neda; Sauter, Jürgen; Hofmann, Jan A; Traherne, James A; González-Quezada, Betsy; Gorodezky, Clara; Bultitude, Will P; Marin, Wesley; Vierra-Green, Cynthia; Anderson, Kirsten M; Balas, Antonio; Caro-Oleas, Jose L; Cisneros, Elisa; Colucci, Francesco; Dandekar, Ravi; Elfishawi, Sally M; Fernández-Viña, Marcelo A; Fouda, Merhan; González-Fernández, Rafael; Große, Arend; Herrero-Mata, Maria J; Hollenbach, Sam Q; Marsh, Steven G E; Mentzer, Alex; Middleton, Derek; Moffett, Ashley; Moreno-Hidalgo, Miguel A; Mossallam, Ghada I; Nakimuli, Annettee; Oksenberg, Jorge R; Oppenheimer, Stephen J; Parham, Peter; Petzl-Erler, Maria-Luiza; Planelles, Dolores; Sánchez-García, Florentino; Sánchez-Gordo, Francisco; Schmidt, Alexander H; Trowsdale, John; Vargas, Luciana B; Vicario, Jose L; Vilches, Carlos; Norman, Paul J; Hollenbach, Jill A.
Afiliación
  • Misra MK; Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
  • Augusto DG; Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA; Department of Genetics, Universidade Federal do Paraná, Curitiba, Brazil.
  • Martin GM; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA.
  • Nemat-Gorgani N; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Sauter J; DKMS gGmbH, Tübingen, Germany.
  • Hofmann JA; DKMS gGmbH, Tübingen, Germany.
  • Traherne JA; Department of Pathology, University of Cambridge, Cambridge, UK.
  • González-Quezada B; Department of Immunology and Immunogenetics, InDRE, Secretary of Health, Francisco P. Miranda #177, Colonia Lomas de Plateros, Del. Álvaro Obregón, CP 01480, Mexico City, Mexico; Fundación Comparte Vida, A.C. Galileo #92, Col. Polanco, Del. Miguel Hidalgo, CP 11550 Mexico City, Mexico.
  • Gorodezky C; Department of Immunology and Immunogenetics, InDRE, Secretary of Health, Francisco P. Miranda #177, Colonia Lomas de Plateros, Del. Álvaro Obregón, CP 01480, Mexico City, Mexico; Fundación Comparte Vida, A.C. Galileo #92, Col. Polanco, Del. Miguel Hidalgo, CP 11550 Mexico City, Mexico.
  • Bultitude WP; Anthony Nolan Research Institute and UCL Cancer Institute, Royal Free Campus, Pond Street, London NW3 2QG, UK.
  • Marin W; Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
  • Vierra-Green C; Center for International Blood and Marrow Transplant Research, Minneapolis, MN, USA.
  • Anderson KM; Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
  • Balas A; Histocompatibility, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain.
  • Caro-Oleas JL; Histocompatibility and Immunogenetics, Banc de Sang i Teixits, Barcelona, Spain.
  • Cisneros E; Immunogenetics and Histocompatibility, Instituto de Investigación Sanitaria Puerta de Hierro, Madrid, Spain.
  • Colucci F; Department of Obstetrics and Gynaecology, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge School of Clinical Medicine, Cambridge, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.
  • Dandekar R; Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
  • Elfishawi SM; National Cancer Institute, Cairo University, Cairo, Egypt.
  • Fernández-Viña MA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA.
  • Fouda M; National Cancer Institute, Cairo University, Cairo, Egypt.
  • González-Fernández R; Immunology, Hospital Universitario Reina Sofía, Córdoba, Spain.
  • Große A; DKMS Life Science Lab, Dresden, Germany.
  • Herrero-Mata MJ; Histocompatibility and Immunogenetics, Banc de Sang i Teixits, Barcelona, Spain.
  • Hollenbach SQ; Macalester College, St. Paul, MN 55105, USA.
  • Marsh SGE; Anthony Nolan Research Institute and UCL Cancer Institute, Royal Free Campus, Pond Street, London NW3 2QG, UK.
  • Mentzer A; Wellcome Trust Centre for Human Genetics, and Jenner Institute, University of Oxford, Oxford, UK.
  • Middleton D; Royal Liverpool University Hospital, Liverpool L7 8XP, UK.
  • Moffett A; Department of Pathology, University of Cambridge, Cambridge, UK; Centre for Trophoblast Research, Cambridge, UK.
  • Moreno-Hidalgo MA; Histocompatibility, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain.
  • Mossallam GI; National Cancer Institute, Cairo University, Cairo, Egypt.
  • Nakimuli A; Department of Obstetrics and Gynecology, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
  • Oksenberg JR; Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
  • Oppenheimer SJ; School of Anthropology and Museum Ethnography, University of Oxford, Oxford, UK.
  • Parham P; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Petzl-Erler ML; Department of Genetics, Universidade Federal do Paraná, Curitiba, Brazil.
  • Planelles D; Histocompatibility, Centro de Transfusión de la Comunidad Valenciana, Valencia, Spain.
  • Sánchez-García F; Immunology, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain.
  • Sánchez-Gordo F; Histocompatibility, Centro de Transfusión de Málaga, Málaga, Spain.
  • Schmidt AH; DKMS gGmbH, Tübingen, Germany; DKMS Life Science Lab, Dresden, Germany.
  • Trowsdale J; Department of Pathology, University of Cambridge, Cambridge, UK.
  • Vargas LB; Department of Genetics, Universidade Federal do Paraná, Curitiba, Brazil.
  • Vicario JL; Histocompatibility, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain.
  • Vilches C; Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
  • Norman PJ; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Biomedical Informatics and Personalized Medicine, and Department of Immunology, University of Colorado, Denver, CO 80045, United States.
  • Hollenbach JA; Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address: jill.hollenbach@ucsf.edu.
Hum Immunol ; 79(12): 825-833, 2018 Dec.
Article en En | MEDLINE | ID: mdl-30321631
ABSTRACT
The goals of the KIR component of the 17th International HLA and Immunogenetics Workshop (IHIW) were to encourage and educate researchers to begin analyzing KIR at allelic resolution, and to survey the nature and extent of KIR allelic diversity across human populations. To represent worldwide diversity, we analyzed 1269 individuals from ten populations, focusing on the most polymorphic KIR genes, which express receptors having three immunoglobulin (Ig)-like domains (KIR3DL1/S1, KIR3DL2 and KIR3DL3). We identified 13 novel alleles of KIR3DL1/S1, 13 of KIR3DL2 and 18 of KIR3DL3. Previously identified alleles, corresponding to 33 alleles of KIR3DL1/S1, 38 of KIR3DL2, and 43 of KIR3DL3, represented over 90% of the observed allele frequencies for these genes. In total we observed 37 KIR3DL1/S1 allotypes, 40 for KIR3DL2 and 44 for KIR3DL3. As KIR allotype diversity can affect NK cell function, this demonstrates potential for high functional diversity worldwide. Allelic variation further diversifies KIR haplotypes. We determined KIR3DL3 ∼ KIR3DL1/S1 ∼ KIR3DL2 haplotypes from five of the studied populations, and observed multiple population-specific haplotypes in each. This included 234 distinct haplotypes in European Americans, 191 in Ugandans, 35 in Papuans, 95 in Egyptians and 86 in Spanish populations. For another 35 populations, encompassing 642,105 individuals we focused on KIR3DL2 and identified another 375 novel alleles, with approximately half of them observed in more than one individual. The KIR allelic level data gathered from this project represents the most comprehensive summary of global KIR allelic diversity to date, and continued analysis will improve understanding of KIR allelic polymorphism in global populations. Further, the wealth of new data gathered in the course of this workshop component highlights the value of collaborative, community-based efforts in immunogenetics research, exemplified by the IHIW.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Familia de Multigenes / Receptores KIR / Antígenos HLA / Inmunogenética Límite: Humans Idioma: En Revista: Hum Immunol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Familia de Multigenes / Receptores KIR / Antígenos HLA / Inmunogenética Límite: Humans Idioma: En Revista: Hum Immunol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos