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Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.
Kummari, Lalith K; Butler, Mark S; Furlong, Emily; Blundell, Ross; Nouwens, Amanda; Silva, Alberto B; Kappler, Ulrike; Fraser, James A; Kobe, Bostjan; Cooper, Matthew A; Robertson, Avril A B.
Afiliación
  • Kummari LK; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Institute for Molecular Biosc
  • Butler MS; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Furlong E; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Blundell R; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Nouwens A; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Silva AB; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia; AC Immune SA, EPFL Innovation Park, CH-1015 Lausanne, Switzerland.
  • Kappler U; Centre for Metals in Biology, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Fraser JA; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Kobe B; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Cooper MA; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Robertson AAB; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address: a.robertson3@uq.edu.au.
Bioorg Med Chem ; 26(20): 5408-5419, 2018 11 01.
Article en En | MEDLINE | ID: mdl-30322754
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiofenos / Proteínas Fúngicas / Cryptococcus neoformans / IMP Deshidrogenasa / Antifúngicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiofenos / Proteínas Fúngicas / Cryptococcus neoformans / IMP Deshidrogenasa / Antifúngicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido