Rational design of coumarin derivatives as antituberculosis agents.
Future Med Chem
; 10(20): 2431-2444, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-30325198
ABSTRACT
AIM:
A series of coumarin derivatives was designed as potential antituberculosis agents.RESULTS:
The compounds were screened against active and dormant Mycobacterium tuberculosis (Mtb). Compounds 3k and 3n were found to have the most promising activity against replicating MtbH37Rv exhibiting minimum inhibitory concentration of 4.63 and 9.75 µM respectively. The compounds were also effective against dormant MtbH37Rv exhibiting more potency than the standard drugs, isoniazid and rifampicin. The compounds were found to be non-cytotoxic against human cell lines.CONCLUSION:
This study provides promising antituberculosis agents that are effective against replicating as well as dormant Mtb and can thus act as potential leads for further development.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cumarinas
/
Mycobacterium tuberculosis
/
Antituberculosos
Límite:
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2018
Tipo del documento:
Article
País de afiliación:
India