Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles.
Langmuir
; 34(44): 13368-13374, 2018 11 06.
Article
en En
| MEDLINE
| ID: mdl-30346771
ABSTRACT
Controlling lateral interactions between lipid molecules in a bilayer membrane to guide membrane organization and domain formation is a key factor for studying and emulating membrane functionality in synthetic biological systems. Here, we demonstrate an approach to reversibly control lipid organization, domain formation, and membrane stiffness of phospholipid bilayer membranes using the photoswitchable phospholipid azo-PC. azo-PC contains an azobenzene group in the sn2 acyl chain that undergoes reversible photoisomerization on illumination with UV-A and visible light. We demonstrate that the concentration of the photolipid molecules and also the assembly and disassembly of photolipids into lipid domains can be monitored by UV-vis spectroscopy because of a blue shift induced by photolipid aggregation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Microdominios de Membrana
/
Liposomas Unilamelares
/
Membrana Dobles de Lípidos
Idioma:
En
Revista:
Langmuir
Asunto de la revista:
QUIMICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania