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Association of Genes implicated in primary angle-closure Glaucoma and the ocular biometric parameters of anterior chamber depth and axial length in a northern Chinese population.
Wang, Shaolin; Zhuang, Wenjuan; Ma, Jianqing; Xu, Manyun; Piao, Shunyu; Hao, Juan; Zhang, Wen; Chi, Hao; Xue, Zhongqi; Ha, Shaoping.
Afiliación
  • Wang S; People's Hospital of Ningxia Hui Autonomous Region, Ningxia Eye Hospital (First Affiliated Hospital of Northwest University For Nationalities), 936 Huang He East Road, Yinchuan, 750011, China.
  • Zhuang W; Clinical Medical College of Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750001, China.
  • Ma J; People's Hospital of Ningxia Hui Autonomous Region, Ningxia Eye Hospital (First Affiliated Hospital of Northwest University For Nationalities), 936 Huang He East Road, Yinchuan, 750011, China. zh_wenj@163.com.
  • Xu M; Department of Ophthalmology, Wuzhong People's Hospital, 430 Wen Wei Road, Wuzhong, 751100, China.
  • Piao S; People's Hospital of Ningxia Hui Autonomous Region, Ningxia Eye Hospital (First Affiliated Hospital of Northwest University For Nationalities), 936 Huang He East Road, Yinchuan, 750011, China.
  • Hao J; Clinical Medical College of Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750001, China.
  • Zhang W; Department of Ophthalmology, Taiyuan Central Hospital, 1 Dong San Dao Lane, Jie Fang North Road, Taiyuan, 030000, China.
  • Chi H; People's Hospital of Ningxia Hui Autonomous Region, Ningxia Eye Hospital (First Affiliated Hospital of Northwest University For Nationalities), 936 Huang He East Road, Yinchuan, 750011, China.
  • Xue Z; Shandong Academy of Medical Sciences, Jinan University, 18877 Jing Shi Road, Li Xia District, Jinan, 250000, China.
  • Ha S; People's Hospital of Ningxia Hui Autonomous Region, Ningxia Eye Hospital (First Affiliated Hospital of Northwest University For Nationalities), 936 Huang He East Road, Yinchuan, 750011, China.
BMC Ophthalmol ; 18(1): 271, 2018 Oct 22.
Article en En | MEDLINE | ID: mdl-30348125
BACKGROUND: The membrane frizzled-related protein (MFRP) gene is involved in axial length (AL) regulation and MFRP mutations cause nanophthalmos; also, the hepatocyte growth factor (HGF) gene is reported to result in morphologic changes of the anterior segment and abnormal aqueous regulation that increases the risk of primary angle-closure glaucoma (PACG), while the zinc ring finger 3 (ZNRF3) gene is associated with AL. The present study investigated the association of single nucleotide polymorphisms (SNPs) in ZNRF3, HGF and MFRP with PACG in a northern Chinese population, as well as the association of these SNPs with the ocular biometric parameters of anterior chamber depth (ACD) and AL. METHODS: A total of 500 PACG patients and 720 controls were recruited. All individuals were genotyped for 12 SNPs in three genes (rs7290117, rs2179129, rs4823006 and rs3178915 in ZNRF3; rs5745718, rs12536657, rs12540393, rs17427817 and rs3735520 in HGF, rs2510143, rs36015759 and rs3814762 in MFRP) using an improved multiplex ligation detection reaction (iMLDR) technique. Genotypic distribution was analyzed for Hardy-Weinberg equilibrium. Differences in the allelic and genotypic frequencies were evaluated and adjusted by age and sex. Linkage disequilibrium (LD) patterns were tested and haplotype analysis was conducted by a logistic regression model. Generalized estimation equation (GEE) analysis was conducted using SPSS for primary association testing between genotypes and ocular biometric parameters. Bonferroni corrections for multiple comparisons were performed, and the statistical power was calculated by power and sample size calculations. RESULTS: The rs7290117 SNP in ZNRF3 was significantly associated with the AL, with a p-value of 0.002. We did not observe any significant associations between the SNPs and PACG or ACD. In a stratification analysis by ethnicity, rs12540393 and rs17427817 in HGF showed a nominal association with PACG in the Hui cohort, although significance was lost after correction. CONCLUSIONS: The present study suggests rs7290117 in ZNRF3 may be involved in the regulation of AL, though our results do not support a contribution of the SNPs we tested in ZNRF3, HGF and MFRP to PACG in northern Chinese people. Further studies in a larger population are warranted to confirm this conclusion.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glaucoma de Ángulo Cerrado / Factor de Crecimiento de Hepatocito / Ubiquitina-Proteína Ligasas / Pueblo Asiatico / Longitud Axial del Ojo / Proteínas de la Membrana / Cámara Anterior Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: BMC Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glaucoma de Ángulo Cerrado / Factor de Crecimiento de Hepatocito / Ubiquitina-Proteína Ligasas / Pueblo Asiatico / Longitud Axial del Ojo / Proteínas de la Membrana / Cámara Anterior Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: BMC Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido