Prostate Luminal Progenitor Cells in Development and Cancer.
Trends Cancer
; 4(11): 769-783, 2018 11.
Article
en En
| MEDLINE
| ID: mdl-30352679
ABSTRACT
Prostate cancer (PCa) has a predominantly luminal phenotype. Basal cells were previously identified as a cell of origin for PCa, but increasing evidence implicates luminal cells as a preferred cell of origin for PCa, as well as key drivers of tumor development and progression. Prostate luminal cells are understudied compared with basal cells. In this review, we describe the contribution of prostate luminal progenitor (LP) cells to luminal cell development and their role in prostate development, androgen-mediated regeneration of castrated prostate, and tumorigenesis. We also discuss the potential value of LP transcriptomics to identify new targets and therapies to treat aggressive PCa. Finally, we propose future research directions focusing on molecular mechanisms underlying LP cell biology and heterogeneity in normal and diseased prostate.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Próstata
/
Neoplasias de la Próstata
/
Células Madre
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Carcinogénesis
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Trends Cancer
Año:
2018
Tipo del documento:
Article