The effect of intraosseous sodium bicarbonate on bone in swine.
Ann Emerg Med
; 16(7): 773-6, 1987 Jul.
Article
en En
| MEDLINE
| ID: mdl-3035967
ABSTRACT
Five domestic swine weighing 8 to 12 kg were anesthetized with ketamine 20 mg/kg IM and pentobarbital 20 mg/kg IV. After a sterile prep each animal received NaHCO3 1 mEq/mL/kg in one tibia and saline 1 mL/kg in the other. The animals were allowed to recover and were observed for 30 days. At the end of this period, roentgenographs were obtained of each tibia and triple phase 99m technetium bone scans were obtained. The tibias also were sectioned, stained, and examined under light microscopy for microscopic abnormalities. The only deficit found was a small cortical calcification at the site of the needle puncture in an animal that received NaHCO3. All other roentgenographs, bone scans, and microscopic specimens were normal. This study demonstrates that NaHCO3 does not have permanent adverse effects when injected into the marrow cavity of swine and supports previous clinical observations regarding the safety of NaHCO3.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sodio
/
Bicarbonatos
/
Huesos
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Ann Emerg Med
Año:
1987
Tipo del documento:
Article