Oocyte developmental competence is independent of ovarian reserve in women younger than 35 years.
Reprod Biomed Online
; 37(6): 677-684, 2018 Dec.
Article
en En
| MEDLINE
| ID: mdl-30366842
ABSTRACT
RESEARCH QUESTION Is higher antral follicle count (AFC) in healthy young women associated with higher oocyte developmental competence? DESIGN:
Retrospective study of 1985 first oocyte donation cycles, corresponding to 3210 fresh embryo transfers in oocyte recipients, conducted between January 2010 and May 2014.RESULTS:
Donors with higher AFC who underwent ovarian stimulation, produced both more cumulus-oocyte complexes (COC) (B coefficientâ¯=â¯0.47, 95% CI 0.41 to 0.53;Pâ¯≤â¯0.001) and MII oocytes (B coefficientâ¯=â¯0.36, 95% CI 0.32 to 0.41;Pâ¯≤â¯0.001) at linear regression analysis. Donors with low AFC had a higher risk of cancellation (OR 4.79, 95% CI 2.99 to 7.69;Pâ¯<â¯0.001) or obtaining fewer than four metaphase II (MII) at ovum retrieval (OR 3.87, 95% CI 2.38 to 6.27;Pâ¯<â¯0.001). No association was found between AFC and biochemical (OR 1.13, 95% CI 0.93 to 1.36), clinical (OR 1.05, 95% CI 0.87 to 1.28), ongoing pregnancy (OR 1.00, 95%, CI 0.82 to 1.21) or live birth rates (OR 0.97, 95% CI 0.8 to 1.19), when at least four MII were obtained at ovum retrieval.CONCLUSIONS:
AFC does not relate to the developmental competence of oocytes in women younger than 35 years.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oocitos
/
Reserva Ovárica
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Reprod Biomed Online
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2018
Tipo del documento:
Article
País de afiliación:
España