Identification of breast tumors from diathermy smoke by differential ion mobility spectrometry.
Eur J Surg Oncol
; 45(2): 141-146, 2019 02.
Article
en En
| MEDLINE
| ID: mdl-30366874
ABSTRACT
INTRODUCTION:
Breast cancer is the most frequent cancer in women worldwide. The primary treatment is breast-conserving surgery or mastectomy with an adequate clearance margin. Diathermy blade is used extensively in breast-conserving surgery. Surgical smoke produced as a side product has cancer-specific molecular features. Differential mobility spectrometry (DMS) is a rapid and affordable technology for analysis of complex gas mixtures. In our study we examined surgical smoke from malignant and benign breast tissue created with a diathermy blade using DMS. MATERIAL ANDMETHODS:
Punch biopsies of 4â¯mm diameter from breast cancer surgical specimens were taken during gross dissection of fresh surgical specimen and placed in a well plate. The measurement system is a custom-built device called automatic tissue analysis system (ATAS) based on a DMS sensor. Each specimen was incised with a diathermy blade and the surgical smoke was analyzed.RESULTS:
We examined 106 carcinoma samples from 21 malignant breast tumors. Benign samples (nâ¯=â¯198) included macroscopically normal mammary gland (nâ¯=â¯82), adipose tissue (nâ¯=â¯88) and vascular tissue (nâ¯=â¯28). The classification accuracy when comparing malignant samples to all benign samples was 87%. The sensitivity was 80% and the specificity was 90%. The classification accuracy of carcinomas to ductal and lobular was 94%, 47%, respectively.CONCLUSIONS:
Benign and malignant breast tissue can be identified with ATAS. These results lay foundation for intraoperative margin assessment with DMS from surgical smoke.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Humo
/
Neoplasias de la Mama
/
Diatermia
/
Espectrometría de Movilidad Iónica
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
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Middle aged
Idioma:
En
Revista:
Eur J Surg Oncol
Asunto de la revista:
NEOPLASIAS
Año:
2019
Tipo del documento:
Article