Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus.
Clin Transl Sci
; 12(1): 28-38, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30369069
ABSTRACT
Our objective was to assess the relationship between hyperbilirubinemia with and without kernicterus and metabolic profile at newborn screening. Included were 1,693,658 infants divided into a training or testing subset in a ratio of 31. Forty-two metabolites were analyzed using logistic regression (odds ratios (ORs), area under the receiver operating characteristic curve (AUC), 95% confidence intervals (CIs)). Several metabolite patterns remained consistent across gestational age groups for hyperbilirubinemia without kernicterus. Thyroid stimulating hormone (TSH) and C-182 were decreased, whereas tyrosine and C-3 were increased in infants across groupings. Increased C-3 was also observed for kernicterus (OR 3.17; 95% CI 1.18-8.53). Thirty-one metabolites were associated with hyperbilirubinemia without kernicterus in the training set. Phenylalanine (OR 1.91; 95% CI 1.85-1.97), ornithine (OR 0.76; 95% 0.74-0.77), and isoleucine + leucine (OR 0.63; 95% CI 0.61-0.65) were the most strongly associated. This study showed that newborn metabolic function is associated with hyperbilirubinemia with and without kernicterus.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tamizaje Neonatal
/
Metaboloma
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Ictericia Neonatal
/
Kernicterus
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
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Male
/
Newborn
Idioma:
En
Revista:
Clin Transl Sci
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos