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Magnetic resonance imaging correlates of neuro-axonal pathology in the MS spinal cord.
Schmierer, Klaus; Miquel, Marc E.
Afiliación
  • Schmierer K; Queen Mary University of London, Barts and The London School of Medicine & Dentistry, Blizard Institute (Neuroscience), London, UK.
  • Miquel ME; Barts Health NHS Trust, Clinical Board Medicine (Neuroscience), The Royal London Hospital, London, UK.
Brain Pathol ; 28(5): 765-772, 2018 09.
Article en En | MEDLINE | ID: mdl-30375114
In people with multiple sclerosis (MS), the spinal cord is the structure most commonly affected by clinically detectable pathology at presentation, and a key part of the central nervous system involved in chronic disease deterioration. Indices, such as the spinal cord cross-sectional area at the level C2 have been developed as tools to predict future disability, and-by inference-axonal loss. However, this and other histo-pathological correlates of spinal cord magnetic resonance imaging (MRI) changes in MS remain incompletely understood. In recent years, there has been a surge of interest in developing quantitative MRI tools to measure specific tissue features, including axonal density, myelin content, neurite density, and orientation, among others, with an emphasis on the spinal cord. Quantitative MRI techniques including T1 and T2 , magnetization transfer and a number of diffusion-derived indices have all been applied to MS spinal cord. Particularly diffusion-based MRI techniques combined with microscopic resolution achievable using high magnetic field scanners enable a new level of anatomical detail and quantification of indices that are clinically meaningful.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Espinal / Imagen por Resonancia Magnética / Esclerosis Múltiple Límite: Animals / Humans Idioma: En Revista: Brain Pathol Asunto de la revista: CEREBRO / PATOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Espinal / Imagen por Resonancia Magnética / Esclerosis Múltiple Límite: Animals / Humans Idioma: En Revista: Brain Pathol Asunto de la revista: CEREBRO / PATOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Suiza