Nucleophilic ring opening of trans-2,3-disubstituted epoxides to ß-amino alcohols with catalyst-controlled regioselectivity.
Chem Commun (Camb)
; 54(92): 12998-13001, 2018 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-30387793
ABSTRACT
We report the nucleophilic ring opening of unsymmetrical trans-epoxides to ß-amino alcohols with catalyst-controlled regioselectivity. This cationic aluminum salen catalyst, which contains bulky mesityl groups in the ortho-position of the phenoxide and a 2,2'-diamino-1,1'-binaphthalene backbone, transforms a variety of epoxides with high regioselectivity using nitrogen-containing nucleophiles. Unlike most reports, in which regioselectivity is substrate controlled, the regioselectivity in this system is catalyst controlled and allows selective nucleophilic ring opening of unbiased trans-epoxides.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos