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Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.
Ashraf-Uz-Zaman, Md; Sajib, Md Sanaullah; Cucullo, Luca; Mikelis, Constantinos M; German, Nadezhda A.
Afiliación
  • Ashraf-Uz-Zaman M; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, United States.
  • Sajib MS; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, United States.
  • Cucullo L; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, United States.
  • Mikelis CM; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, United States.
  • German NA; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, United States. Electronic address: nadezhda.german@ttuhsc.edu.
Bioorg Med Chem Lett ; 28(23-24): 3652-3657, 2018 12 15.
Article en En | MEDLINE | ID: mdl-30389290
Several recent reports have highlighted the feasibility of the use of penfluridol, a well-known antipsychotic agent, as a chemotherapeutic agent. In vivo experiments have confirmed the cytotoxic activity of penfluridol in triple-negative breast cancer model, lung cancer model, and further studies have been proposed to assess its anticancer activity and viability for the treatment of glioblastomas. However, penfluridol anticancer activity was observed at a dosage significantly higher than that administered in antipsychotic therapy, thus raising the concern for the potential onset of CNS side effects in patients undergoing intensive pharmacological treatment. In this study, we evaluate the potential CNS toxicity of penfluridol side by side with a set of analogs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penfluridol / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penfluridol / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido