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Differences in von Willebrand factor function in type 2A von Willebrand disease and left ventricular assist device-induced acquired von Willebrand syndrome.
Deconinck, Shannen; Tersteeg, Claudia; Bailleul, Els; Delrue, Leen; Vandeputte, Nele; Pareyn, Inge; Itzhar-Baikian, Nathalie; Deckmyn, Hans; De Meyer, Simon F; Vanderheyden, Marc; Vanhoorelbeke, Karen.
Afiliación
  • Deconinck S; Laboratory for Thrombosis Research IRF Life Sciences KU Leuven Campus Kulak Kortrijk Kortrijk Belgium.
  • Tersteeg C; Laboratory for Thrombosis Research IRF Life Sciences KU Leuven Campus Kulak Kortrijk Kortrijk Belgium.
  • Bailleul E; Cardiovascular Center Aalst OLV Hospital Aalst Belgium.
  • Delrue L; Cardiovascular Center Aalst OLV Hospital Aalst Belgium.
  • Vandeputte N; Laboratory for Thrombosis Research IRF Life Sciences KU Leuven Campus Kulak Kortrijk Kortrijk Belgium.
  • Pareyn I; Laboratory for Thrombosis Research IRF Life Sciences KU Leuven Campus Kulak Kortrijk Kortrijk Belgium.
  • Itzhar-Baikian N; Service d'hématologie biologique, Hôpital Lariboisière and EA3518-Institut universitaire d'hématologie Groupe Hospitalier Saint Louis-Lariboisière Assistance Publique-Hôpitaux de Paris Université Paris Diderot Paris France.
  • Deckmyn H; Laboratory for Thrombosis Research IRF Life Sciences KU Leuven Campus Kulak Kortrijk Kortrijk Belgium.
  • De Meyer SF; Laboratory for Thrombosis Research IRF Life Sciences KU Leuven Campus Kulak Kortrijk Kortrijk Belgium.
  • Vanderheyden M; Cardiovascular Center Aalst OLV Hospital Aalst Belgium.
  • Vanhoorelbeke K; Laboratory for Thrombosis Research IRF Life Sciences KU Leuven Campus Kulak Kortrijk Kortrijk Belgium.
Res Pract Thromb Haemost ; 2(4): 762-766, 2018 Oct.
Article en En | MEDLINE | ID: mdl-30397685
BACKGROUND: Patients with von Willebrand disease (VWD) type 2A or acquired von Willebrand syndrome (aVWS) as a consequence of implantation of left ventricular assist devices (LVAD) are both characterized by a loss of von Willebrand factor (VWF) function. Loss of VWF function is however more severe in VWD type 2A than in LVAD patients. OBJECTIVES: To compare VWF function in patients with VWD type 2A and LVAD-induced aVWS to highlight the differences in VWF activity and to stress the importance of VWF multimer analysis for correct diagnosis of aVWS in LVAD patients. PATIENTS/METHODS: Plasma samples from nine VWD type 2A, nine LVAD patients, and 20 healthy donors (HD) were analyzed for VWF function (VWF:CB/VWF:Ag and VWF:RCo/VWF:Ag) and loss of high molecular weight (HMW) VWF multimers. RESULTS: A severely impaired VWF function was indeed confirmed in all VWD 2A patients. HMW VWF multimers were severely reduced compared to HD (0% [0, 12.29] vs 34.19% [31.68, 38.88] for HD, P < 0.001) and this loss was reflected by VWF:CB/VWF:Ag and VWF:RCo/VWF:Ag ratios <0.7. In contrast, VWF function was less affected in LVAD patients. Although HMW VWF multimers were reduced in all patients (20.31% [15.84, 21.71], vs 34.19% [31.68, 38.88] for HD, P < 0.001), six out of nine LVAD patients had normal VWF:CB/VWF:Ag or VWF:RCo/VWF:Ag ratios (>0.7). CONCLUSIONS: VWF:CB/VWF:Ag or VWF:RCo/VWF:Ag analysis allows detection of impaired VWF function in VWD type 2A but not always in LVAD-induced aVWS patients. In contrast, VWF multimeric analysis allows detection of the loss of HMW VWF multimers in both groups of patients. Hence, performing VWF multimer analysis is crucial to detect aVWS in LVAD patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Res Pract Thromb Haemost Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Res Pract Thromb Haemost Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos