Gastric carcinoma with a gastrointestinal stromal tumor - A case report and literature review.
Med Sci (Paris)
; 34 Focus issue F1: 15-19, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-30403169
ABSTRACT
Gastric carcinoma (GC) with gastrointestinal stromal tumor (GIST) is encountered very rarely in the clinic, and few cases have been reported in the literature. Here, we present a case involving a 72-year-old man who was diagnosed with gastric antrum adenocarcinoma accompanied by neuroendocrine differentiation and a GIST in the fundus, according to a preoperative examination and postoperative pathology. The patient then underwent a distal radical gastrectomy and GIST resection. After the operation, the patient was administered combined chemo-radiotherapy and subsequently underwent a 9-month follow-up examination. The gene mutations involved in this case were explored via high-throughput sequencing. The high-throughput gene mutation analysis indicated an exon5 mutation in the TP53 gene and copy number amplification of FGF19, CCND1, and FGFR2 in the gastric antrum adenocarcinoma. A gene sequencing analysis of the gastric fundus stromal tumor demonstrated an exon11 non-frame shift deletion mutation in the KIT gene. These findings suggested that this patient's cancer might be sensitive to AZD1775 (a TP53-targeted drug) or targeted drugs such as FGF19, CCND1 and FGFR2, and should be sensitive to imatinib.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
/
Tumores del Estroma Gastrointestinal
/
Neoplasias Gastrointestinales
/
Neoplasias Primarias Múltiples
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Systematic_reviews
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Med Sci (Paris)
Asunto de la revista:
MEDICINA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China