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Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.
Choi, Hae Woong; Suwanpradid, Jutamas; Kim, Il Hwan; Staats, Herman F; Haniffa, Muzlifah; MacLeod, Amanda S; Abraham, Soman N.
Afiliación
  • Choi HW; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. haewoong.choi@duke.edu.
  • Suwanpradid J; Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA.
  • Kim IH; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
  • Staats HF; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
  • Haniffa M; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
  • MacLeod AS; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
  • Abraham SN; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Science ; 362(6415)2018 11 09.
Article en En | MEDLINE | ID: mdl-30409859
Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b+ perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and trigger anaphylaxis. DC antigen transfer involves the active discharge of surface-associated antigens on 0.5- to 1.0-micrometer microvesicles (MVs) generated by vacuolar protein sorting 4 (VPS4). Antigen sharing by DCs is not limited to MCs, as neighboring DCs also acquire antigen-bearing MVs. This capacity of DCs to distribute antigen-bearing MVs to various immune cells in the perivascular space potentiates inflammatory and immune responses to blood-borne antigens.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Células Dendríticas / Alérgenos / Micropartículas Derivadas de Células / Anafilaxia / Mastocitos Límite: Animals / Female / Humans / Male Idioma: En Revista: Science Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Células Dendríticas / Alérgenos / Micropartículas Derivadas de Células / Anafilaxia / Mastocitos Límite: Animals / Female / Humans / Male Idioma: En Revista: Science Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos