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KPC-producing Klebsiella pneumoniae gut decolonisation following ceftazidime/avibactam-based combination therapy: A retrospective observational study.
Bassetti, Matteo; Carannante, Novella; Pallotto, Carlo; Righi, Elda; Di Caprio, Giovanni; Bernardo, Mariano; Sodano, Giuseppe; Mallardo, Enza; Francisci, Daniela; Sartor, Assunta; Graziano, Elena; Tascini, Carlo.
Afiliación
  • Bassetti M; Infectious Diseases Division, Department of Medicine, University of Udine and Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy.
  • Carannante N; First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, 80131 Naples, Italy.
  • Pallotto C; First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, 80131 Naples, Italy; Infectious Diseases Section, Department of Medicine, University of Perugia, Piazzale Gambuli 1, Perugia, Italy. Electronic address: carlop85@hotmail.it.
  • Righi E; Infectious Diseases Division, Department of Medicine, University of Udine and Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy.
  • Di Caprio G; Infectious Diseases Section, Department of Mental Health and Public Medicine, University of Campania 'Luigi Vanvitelli', largo Madonna delle Grazie, Naples, Italy.
  • Bernardo M; Microbiology and Virology Unit, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, Naples, Italy.
  • Sodano G; Microbiology and Virology Unit, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, Naples, Italy.
  • Mallardo E; Microbiology and Virology Unit, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, Naples, Italy.
  • Francisci D; Infectious Diseases Section, Department of Medicine, University of Perugia, Piazzale Gambuli 1, Perugia, Italy.
  • Sartor A; Infectious Diseases Division, Department of Medicine, University of Udine and Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy.
  • Graziano E; Infectious Diseases Division, Department of Medicine, University of Udine and Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy.
  • Tascini C; First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, 80131 Naples, Italy.
J Glob Antimicrob Resist ; 17: 109-111, 2019 06.
Article en En | MEDLINE | ID: mdl-30468915
ABSTRACT

OBJECTIVES:

KPC-producing Klebsiella pneumoniae (KPC-Kp) gut colonisation is a major risk factor for developing systemic infection. Ceftazidime/avibactam (CAZ/AVI) may have a role as decolonisation therapy in special situations.

METHODS:

This was a retrospective, observational, multicentre study. The KPC-Kp gut decolonisation rate of CAZ/AVI-based therapy (Group A) was compared with other antimicrobial regimens (Group B) in patients with KPC-Kp infection.

RESULTS:

Among 12 patients in Group A, 11 (91.7%) achieved gut decolonisation. None of the 24 patients of Group B were decolonised.

CONCLUSION:

CAZ/AVI-based therapy could be useful in KPC-Kp gut decolonisation in high-risk patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Klebsiella / Ceftazidima / Tracto Gastrointestinal / Compuestos de Azabiciclo / Klebsiella pneumoniae / Antibacterianos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Glob Antimicrob Resist Año: 2019 Tipo del documento: Article País de afiliación: Italia
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Klebsiella / Ceftazidima / Tracto Gastrointestinal / Compuestos de Azabiciclo / Klebsiella pneumoniae / Antibacterianos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Glob Antimicrob Resist Año: 2019 Tipo del documento: Article País de afiliación: Italia