The cerebral endothelial cell as a key regulator of inflammatory processes in sterile inflammation.
J Neuroimmunol
; 326: 38-44, 2019 01 15.
Article
en En
| MEDLINE
| ID: mdl-30472304
ABSTRACT
Cerebral endothelial cells accomplish numerous tasks connected to the maintenance of homeostasis of the central nervous system. They create a barrier between the central nervous system and peripheral blood and regulate mechanotransduction, vascular permeability, rheology, thrombogenesis, and leukocyte adhesion. In pathophysiological conditions (e.g., stroke or ischemia-reperfusion injury) the endothelial functions are impaired, leading to increased vascular permeability, vascular inflammation, leukocyte-endothelium interactions, and transendothelial migration, driving CNS inflammation and neuronal destruction. This review describes the current knowledge on the regulatory roles of endothelial cells in neuroinflammatory processes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Células Endoteliales
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Inflamación
Límite:
Animals
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Humans
Idioma:
En
Revista:
J Neuroimmunol
Año:
2019
Tipo del documento:
Article