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Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma.
Wang, Sumei; O'Rourke, Donald M; Chawla, Sanjeev; Verma, Gaurav; Nasrallah, MacLean P; Morrissette, Jennifer J D; Plesa, Gabriela; June, Carl H; Brem, Steven; Maloney, Eileen; Desai, Arati; Wolf, Ronald L; Poptani, Harish; Mohan, Suyash.
Afiliación
  • Wang S; Department of Radiology, Division of Neuroradiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • O'Rourke DM; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Chawla S; Department of Radiology, Division of Neuroradiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Verma G; Department of Radiology, Division of Neuroradiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Nasrallah MP; Department of Pathology and Laboratory Medicine, Division of Neuropathology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Morrissette JJD; Department of Pathology and Laboratory Medicine, Division of Precision and Computational Diagnostics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Plesa G; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.
  • June CH; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.
  • Brem S; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Maloney E; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Desai A; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Wolf RL; Department of Radiology, Division of Neuroradiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Poptani H; Department of Radiology, Division of Neuroradiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Mohan S; Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool, UK.
Br J Cancer ; 120(1): 54-56, 2019 01.
Article en En | MEDLINE | ID: mdl-30478409
ABSTRACT
EGFRvIII targeted chimeric antigen receptor T (CAR-T) cell therapy has recently been reported for treating glioblastomas (GBMs); however, physiology-based MRI parameters have not been evaluated in this setting. Ten patients underwent multiparametric MRI at baseline, 1, 2 and 3 months after CAR-T therapy. Logistic regression model derived progression probabilities (PP) using imaging parameters were used to assess treatment response. Four lesions from "early surgery" group demonstrated high PP at baseline suggestive of progression, which was confirmed histologically. Out of eight lesions from remaining six patients, three lesions with low PP at baseline remained stable. Two lesions with high PP at baseline were associated with large decreases in PP reflecting treatment response, whereas other two lesions with high PP at baseline continued to demonstrate progression. One patient didn't have baseline data but demonstrated progression on follow-up. Our findings indicate that multiparametric MRI may be helpful in monitoring CAR-T related early therapeutic changes in GBM patients.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoterapia Adoptiva / Glioblastoma / Receptores ErbB / Recurrencia Local de Neoplasia Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoterapia Adoptiva / Glioblastoma / Receptores ErbB / Recurrencia Local de Neoplasia Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos