High salt diet impairs cerebral blood flow regulation via salt-induced angiotensin II suppression.
Microcirculation
; 26(3): e12518, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30481399
ABSTRACT
OBJECTIVES:
This study sought to determine whether salt-induced ANG II suppression contributes to impaired CBF autoregulation.METHODS:
Cerebral autoregulation was evaluated with LDF during graded reductions of blood pressure. Autoregulatory responses in rats fed HS (4% NaCl) diet vs LS (0.4% NaCl) diet were analyzed using linear regression analysis, model-free analysis, and a mechanistic theoretical model of blood flow through cerebral arterioles.RESULTS:
Autoregulation was intact in LS-fed animals as MAP was reduced via graded hemorrhage to approximately 50 mm Hg. Short-term (3 days) and chronic (4 weeks) HS diet impaired CBF autoregulation, as evidenced by progressive reductions of laser Doppler flux with arterial pressure reduction. Chronic low dose ANG II infusion (5 mg/kg/min, i.v.) restored CBF autoregulation between the pre-hemorrhage MAP and 50 mm Hg in rats fed short-term HS diet. Mechanistic-based model analysis showed a reduced myogenic response and reduced baseline VSM tone with short-term HS diet, which was restored by ANG II infusion.CONCLUSIONS:
Short-term and chronic HS diet lead to impaired autoregulation in the cerebral circulation, with salt-induced ANG II suppression as a major factor in the initiation of impaired CBF regulation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Presión Sanguínea
/
Angiotensina II
/
Arterias Cerebrales
/
Circulación Cerebrovascular
/
Cloruro de Sodio Dietético
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Microcirculation
Asunto de la revista:
ANGIOLOGIA
Año:
2019
Tipo del documento:
Article