MicroRNA154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7.
Oncol Rep
; 41(2): 819-828, 2019 Feb.
Article
en En
| MEDLINE
| ID: mdl-30483807
ABSTRACT
Aberrant expression of miR154 is usually found in cancer studies; however, the role of miR154 has seldom been reported in bladder cancer (BCa). In this study, we observed that miR154 expression was significantly downregulated in BCa tissues and cell lines, and was associated with several clinicopathological characteristics, including advanced T stage, lymphatic invasion, and distant metastasis. Low expression level of miR154 was associated with poor survival outcomes in BCa patients. Overexpression of miR154 led to significant decrease in the proliferation, migration, and invasion of BCa cells, while knockdown of miR154 yielded the opposite effect. ATG7 was identified as a direct target of miR154. ATG7 expression was negatively correlated with miR154 expression in BCa tissues. Silencing of ATG7 achieved a similar effect to miR154 overexpression; overexpression of ATG7 reversed the inhibitory effect of miR154 on BCa cell proliferation, migration and invasion. A xenograft study revealed that miR154 inhibited BCa cell growth in vivo, and suppressed ATG7 expression. Altogether, this study demonstrated that miR154 may function as a tumor suppressor in BCa and indicated that miR154 may be a potential therapeutic target for BCa patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
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Regulación Neoplásica de la Expresión Génica
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Genes Supresores de Tumor
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MicroARNs
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Proteína 7 Relacionada con la Autofagia
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Oncol Rep
Asunto de la revista:
NEOPLASIAS
Año:
2019
Tipo del documento:
Article