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Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression.
Pawluski, Jodi L; Brain, Ursula; Hammond, Geoffrey L; Oberlander, Tim F.
Afiliación
  • Pawluski JL; Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), University Rennes, UMR_S 1085, F-35000, Rennes, France. j.pawluski@gmail.com.
  • Brain U; Department of Pediatrics, BC Children's Hospital, The University of British Columbia, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
  • Hammond GL; Department of Cellular and Physiological Sciences, Faculty of Medicine, The University of British Columbia, Vancouver, Canada.
  • Oberlander TF; Department of Pediatrics, BC Children's Hospital, The University of British Columbia, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
Arch Womens Ment Health ; 22(3): 431-435, 2019 06.
Article en En | MEDLINE | ID: mdl-30506371
ABSTRACT
The effect of perinatal selective serotonin reuptake inhibitors (SSRIs) on brain-derived neurotrophic factor (BDNF) and S100 calcium binding protein B (S100B) has not been investigated. Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. This shows that serum S100B could be a unique biomarker to determine efficacy of SSRIs during gestation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores Selectivos de la Recaptación de Serotonina / Factor Neurotrófico Derivado del Encéfalo / Depresión / Subunidad beta de la Proteína de Unión al Calcio S100 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Arch Womens Ment Health Asunto de la revista: PSICOLOGIA / SAUDE DA MULHER Año: 2019 Tipo del documento: Article País de afiliación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores Selectivos de la Recaptación de Serotonina / Factor Neurotrófico Derivado del Encéfalo / Depresión / Subunidad beta de la Proteína de Unión al Calcio S100 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Arch Womens Ment Health Asunto de la revista: PSICOLOGIA / SAUDE DA MULHER Año: 2019 Tipo del documento: Article País de afiliación: Francia