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Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. oralis.
Tran, Truc T; Mishra, Nagendra N; Seepersaud, Ravin; Diaz, Lorena; Rios, Rafael; Dinh, An Q; Garcia-de-la-Maria, Cristina; Rybak, Michael J; Miro, Jose M; Shelburne, Samuel A; Sullam, Paul M; Bayer, Arnold S; Arias, Cesar A.
Afiliación
  • Tran TT; Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, Texas, USA.
  • Mishra NN; LA Biomedical Research Institute, Torrance, California, USA.
  • Seepersaud R; Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Diaz L; University of California, San Francisco, California, USA.
  • Rios R; VA Medical Center, San Francisco, California, USA.
  • Dinh AQ; Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, Texas, USA.
  • Garcia-de-la-Maria C; Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
  • Rybak MJ; Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago, Chile.
  • Miro JM; Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, Texas, USA.
  • Shelburne SA; Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
  • Sullam PM; Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago, Chile.
  • Bayer AS; Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, Texas, USA.
  • Arias CA; Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
Antimicrob Agents Chemother ; 63(2)2019 02.
Article en En | MEDLINE | ID: mdl-30509945
ABSTRACT
We investigated the ability of several recent clinical viridans group streptococci (VGS) bloodstream isolates (Streptococcus mitis/S. oralis subgroup) from daptomycin (DAP)-naive patients to develop DAP resistance in vitro All strains rapidly developed high-level and stable DAP resistance. Substitutions in two enzymes involved in the cardiolipin biosynthesis pathway were identified, i.e., CdsA (phosphatidate cytidylyltransferase) and PgsA (CDP-diacylglycerol-glycerol-3-phosphate-3-phosphatidyltransferase). These mutations were associated with complete disappearance of phosphatidylglycerol and cardiolipin from cell membranes. DAP interactions with the cell membrane differed in isolates with PgsA versus CdsA substitutions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transferasas (Grupos de Otros Fosfatos Sustitutos) / Daptomicina / Streptococcus oralis / Streptococcus mitis / Antibacterianos / Nucleotidiltransferasas Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transferasas (Grupos de Otros Fosfatos Sustitutos) / Daptomicina / Streptococcus oralis / Streptococcus mitis / Antibacterianos / Nucleotidiltransferasas Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos