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Buccal Bullfrog (Rana catesbeiana Shaw) Oil Emulsion: A Mucoadhesive System Intended for Treatment of Oral Candidiasis.
Moreira-Oliveira, Susiane S; Amaral-Machado, Lucas; de Oliveira, Wógenes Nunes; Alencar, Éverton N; Zatta, Kelly Cristine; de Souza, Luanda B F C; Medeiros, Aldo da Cunha; Chaves, Guilherme Maranhão; Egito, Eryvaldo S T.
Afiliación
  • Moreira-Oliveira SS; Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Av. General Gustavo Cordeiro de Faria-SN-Petrópolis, Natal 59012-570, Brazil. susiane.m@gmail.com.
  • Amaral-Machado L; Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Av. General Gustavo Cordeiro de Faria-SN-Petrópolis, Natal 59012-570, Brazil. machado.lucasam@gmail.com.
  • de Oliveira WN; Graduate Program in Pharmaceutical Sciences, UFRN, Av. General Gustavo Cordeiro de Faria-SN-Petrópolis, Natal 59012-570, Brazil. wogenes95@gmail.com.
  • Alencar ÉN; Laboratory of Dispersed Systems (LaSiD), UFRN, Av. General Gustavo Cordeiro de Faria-SN-Petrópolis, Natal 59012-570, Brazil. everton_alencar@hotmail.com.
  • Zatta KC; Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Av. Ipiranga-2752-Santana, Porto Alegre 90610-000, Brazil. kellycriz@hotmail.com.
  • de Souza LBFC; Graduate Program in Pharmaceutical Sciences, UFRN, Av. General Gustavo Cordeiro de Faria-SN-Petrópolis, Natal 59012-570, Brazil. luanda_canario@hotmail.com.
  • Medeiros ADC; Department of Surgery, UFRN Av. General Gustavo Cordeiro de Faria-SN-Petrópolis, Natal 59012-570, Brazil. aldom@uol.com.br.
  • Chaves GM; Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Av. General Gustavo Cordeiro de Faria-SN-Petrópolis, Natal 59012-570, Brazil. guilherme.chaves@ufrnet.br.
  • Egito EST; Graduate Program in Pharmaceutical Sciences, UFRN, Av. General Gustavo Cordeiro de Faria-SN-Petrópolis, Natal 59012-570, Brazil. guilherme.chaves@ufrnet.br.
Pharmaceutics ; 10(4)2018 Dec 03.
Article en En | MEDLINE | ID: mdl-30513861
Oral candidiasis (OC) is an infectious disease caused by microorganisms of the genus Candida, leading to lesions in the buccal cavity. Its treatment consists of the administration of topical or systemic antifungal agents, which may compromise the patient compliance due to its side effects, highlighting the need for alternative treatments. In this scenario, bullfrog oil, an animal oil composed of a pool of saturated and unsaturated fatty acids, is introduced as a potential antifungal raw material. Thus, the aim of this work was to produce a mucoadhesive emulsified system able to deliver the bullfrog oil in the buccal cavity to treat the OC. The emulsion was produced and characterized by visual inspection, droplet size, polydispersity index (PdI), and zeta potential over the course of 60 days. In addition, its mucoadhesive ability was evaluated using an in vitro mucin model. The antifungal activity, evaluated by the broth microdilution assay and the biocompatibility, performed against human erythrocytes, were also carried out. The emulsion showed a droplet size of 320.79 ± 35.60 nm, a PdI of 0.49 ± 0.08, and a zeta potential of -38.53 ± 6.23 mV, with no significant changes over 60 days. The mucoadhesive properties of the system was improved by the use of pharmaceutical excipients. The antifungal activity showed that the bullfrog oil and the emulsion were able to inhibit the growth of different Candida species. Furthermore, the emulsion showed no significant hemolytic effect. Overall, the system showed suitable physicochemical characteristics and biocompatibility, with substantial in vitro antifungal activity, suggesting that this system can be further investigated for OC treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Pharmaceutics Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Pharmaceutics Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza