A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-&#954;B mediated apoptosis-to-pyroptosis switch.

Chen, Liping; Weng, Bixia; Li, Huimin; Wang, Haonan; Li, Qian; Wei, Xiaoyan; Deng, Hui; Wang, Sicen; Jiang, Chengxi; Lin, Renyu; Wu, Jianzhang

A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch.

Chen, Liping; Weng, Bixia; Li, Huimin; Wang, Haonan; Li, Qian; Wei, Xiaoyan; Deng, Hui; Wang, Sicen; Jiang, Chengxi; Lin, Renyu; Wu, Jianzhang.

Afiliación

Chen L; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Weng B; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Li H; Department of Pharmaceutical Sciences, Tonglu First Peoples Hospital, Hangzhou, 311500, Zhejiang, China.
Wang H; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Li Q; Department of Periodontics, Hospital & School of Stomatology, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Wei X; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Deng H; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Wang S; Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Jiang C; Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Lin R; Department of Periodontics, Hospital & School of Stomatology, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Wu J; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710049, Shanxi, China.

Apoptosis ; 24(1-2): 74-82, 2019 02.

Article en En | MEDLINE | ID: mdl-30519834

Asunto(s)

Apoptosis/efectos de los fármacos; Neoplasias Pulmonares/tratamiento farmacológico; Piranos/uso terapéutico; Piroptosis/efectos de los fármacos; Compuestos de Sulfhidrilo/química; Células A549; Animales; Antineoplásicos/química; Antineoplásicos/farmacología; Antineoplásicos/uso terapéutico; Apoptosis/fisiología; Línea Celular Tumoral; Femenino; Humanos; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patología; Ratones; Ratones Endogámicos BALB C; FN-kappa B/metabolismo; Piranos/química; Piranos/farmacología; Piroptosis/fisiología; Células RAW 264.7; Transducción de Señal/efectos de los fármacos; Compuestos de Sulfhidrilo/farmacología; Compuestos de Sulfhidrilo/uso terapéutico; Pruebas de Toxicidad; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Anti-lung cancer; Apoptosis; NF-κB; Pyroptosis; Toxicity

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piranos / Compuestos de Sulfhidrilo / Apoptosis / Piroptosis / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Apoptosis Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google