On your marks, get SET(D1A): the race to protect stalled replication forks.
Mol Cell Oncol
; 5(6): e1511209, 2018.
Article
en En
| MEDLINE
| ID: mdl-30525090
We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome integrity with important implications in chemo-sensitivity.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Aspecto:
Determinantes_sociais_saude
Idioma:
En
Revista:
Mol Cell Oncol
Año:
2018
Tipo del documento:
Article
Pais de publicación:
Estados Unidos