Your browser doesn't support javascript.
loading
On your marks, get SET(D1A): the race to protect stalled replication forks.
Begum, Shabana; Goula, Amalia; Bayley, Rachel; Higgs, Martin R.
Afiliación
  • Begum S; Lysine Methylation and DNA Damage Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Goula A; Lysine Methylation and DNA Damage Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Bayley R; Lysine Methylation and DNA Damage Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Higgs MR; Lysine Methylation and DNA Damage Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Mol Cell Oncol ; 5(6): e1511209, 2018.
Article en En | MEDLINE | ID: mdl-30525090
We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome integrity with important implications in chemo-sensitivity.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Aspecto: Determinantes_sociais_saude Idioma: En Revista: Mol Cell Oncol Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Aspecto: Determinantes_sociais_saude Idioma: En Revista: Mol Cell Oncol Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos