[Therapy of hairy cell leukemia with interferon]. / Therapie der Haarzell-Leukämie mit Interferon.
Onkologie
; 11(4): 159-65, 1988 Aug.
Article
en De
| MEDLINE
| ID: mdl-3054667
ABSTRACT
Hairy cell leukemia is a rare lymphoproliferative disorder which is morphologically characterized by circulating lymphatic cells with prominent 'hairy' cytoplasmatic projections. Patients typically present with pancytopenia and splenomegaly. The bone marrow cannot be aspirated because of reticulin fibrosis. Chemotherapy was unable to influence the course of the disease satisfactorily. Therefore, splenectomy was the treatment of choice. The introduction of alpha-interferons into the therapy of hairy cell leukemia was a decisive breakthrough and is exemplary for the use of interferons in the treatment of malignant diseases. However, there are still many questions to be answered. The discussion of clinical implications is achieving growing importance in consequence of the availability of diverse commercial alpha-interferons for treatment of hairy cell leukemia.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia de Células Pilosas
/
Interferón Tipo I
/
Interferón-alfa
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
De
Revista:
Onkologie
Año:
1988
Tipo del documento:
Article