Your browser doesn't support javascript.
loading
Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men.
Noerman, Stefania; Kärkkäinen, Olli; Mattsson, Anton; Paananen, Jussi; Lehtonen, Marko; Nurmi, Tarja; Tuomainen, Tomi-Pekka; Voutilainen, Sari; Hanhineva, Kati; Virtanen, Jyrki K.
Afiliación
  • Noerman S; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70210, Finland.
  • Kärkkäinen O; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70210, Finland.
  • Mattsson A; Bioinformatics Center, University of Eastern Finland, Kuopio, 70210, Finland.
  • Paananen J; Department of Mathematics and System Analysis, Aalto University, Aalto, 00076, Finland.
  • Lehtonen M; Bioinformatics Center, University of Eastern Finland, Kuopio, 70210, Finland.
  • Nurmi T; School of Pharmacy, University of Eastern Finland, Kuopio, 70210, Finland.
  • Tuomainen TP; LC-MS Metabolomics Center, Biocenter Kuopio, Kuopio, 70210, Finland.
  • Voutilainen S; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70210, Finland.
  • Hanhineva K; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70210, Finland.
  • Virtanen JK; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70210, Finland.
Mol Nutr Food Res ; 63(5): e1800605, 2019 03.
Article en En | MEDLINE | ID: mdl-30548819
SCOPE: Higher egg intake was previously associated with a lower risk of developing type 2 diabetes (T2D) in the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) in eastern Finland. Potential compounds that can explain this association are explored using nontargeted LC-MS-based metabolic profiling. METHODS AND RESULTS: Two hundred and thirty-nine baseline serum samples from the KIHD are analyzed in four groups: subjects with higher (mean intake one egg per day) or lower (mean intake two eggs per week) egg intake who developed T2D (cases) or remained heatlhy (controls) during the mean follow-up of 19.3 years. Different serum profiles of subjects who had either higher or lower egg intakes, and of those who developed type 2 diabetes or remained healthy, are observed. The higher baseline tyrosine level predicts higher odds of T2D (OR 1.94; 95% CI 1.45, 2.60; p < 0.001; FDR 0.023) along with an unknown hexose-containing compound (OR 2.13; 95% CI 1.57, 2.88; p < 0.001; FDR 0.005). Certain predominant metabolites in T2D cases are correlated positively with ones in the lower-egg-intake group and negatively with ones in the higher-egg-intake group. CONCLUSION: Our current findings may underline some potential metabolites that can explain how egg intake is associated with a lower risk of T2D.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Huevos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2019 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Huevos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2019 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Alemania