Beneficial effects of prostacyclin in a rabbit endotoxin shock model.
Thromb Res
; 51(4): 403-15, 1988 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-3055416
ABSTRACT
Thirty rabbits received an infusion of lipopolysaccharide B (75 micrograms/kg.h) over 4 hours (groups E, EI, EA; n = 10 each). Saline was given to a control group (C; n = 8). In group EI, prostacyclin (PGI2; 500 ng/kg.min) was given simultaneously to endotoxin. Into group EA animals, aspirin (20 mg/kg) was injected before the endotoxin infusion was started. PGI2 and aspirin both improved survival of animals (6/10 each vs. 2/10 in group E). The drop of platelet counts was significantly reduced by PGI2, while leukocyte depletion was similar in all endotoxin groups. PGI2 preserved the functional capacity of platelets as indicated by collagen stimulated aggregation and thromboxane formation. PGI2 but not aspirin significantly reduced renal fibrin deposition.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Choque Séptico
/
Epoprostenol
Límite:
Animals
Idioma:
En
Revista:
Thromb Res
Año:
1988
Tipo del documento:
Article