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Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
Giri, Ayush; Hellwege, Jacklyn N; Keaton, Jacob M; Park, Jihwan; Qiu, Chengxiang; Warren, Helen R; Torstenson, Eric S; Kovesdy, Csaba P; Sun, Yan V; Wilson, Otis D; Robinson-Cohen, Cassianne; Roumie, Christianne L; Chung, Cecilia P; Birdwell, Kelly A; Damrauer, Scott M; DuVall, Scott L; Klarin, Derek; Cho, Kelly; Wang, Yu; Evangelou, Evangelos; Cabrera, Claudia P; Wain, Louise V; Shrestha, Rojesh; Mautz, Brian S; Akwo, Elvis A; Sargurupremraj, Muralidharan; Debette, Stéphanie; Boehnke, Michael; Scott, Laura J; Luan, Jian'an; Zhao, Jing-Hua; Willems, Sara M; Thériault, Sébastien; Shah, Nabi; Oldmeadow, Christopher; Almgren, Peter; Li-Gao, Ruifang; Verweij, Niek; Boutin, Thibaud S; Mangino, Massimo; Ntalla, Ioanna; Feofanova, Elena; Surendran, Praveen; Cook, James P; Karthikeyan, Savita; Lahrouchi, Najim; Liu, Chunyu; Sepúlveda, Nuno; Richardson, Tom G; Kraja, Aldi.
Afiliación
  • Giri A; Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Hellwege JN; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
  • Keaton JM; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
  • Park J; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN, USA.
  • Qiu C; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
  • Warren HR; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN, USA.
  • Torstenson ES; Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA, USA.
  • Kovesdy CP; Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA, USA.
  • Sun YV; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Wilson OD; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK.
  • Robinson-Cohen C; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
  • Roumie CL; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN, USA.
  • Chung CP; Nephrology Section, Memphis VA Medical Center, Memphis, TN, USA.
  • Birdwell KA; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
  • Damrauer SM; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.
  • DuVall SL; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
  • Klarin D; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Cho K; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Wang Y; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Evangelou E; Geriatrics Research Education and Clinical Center, Tennessee Valley Health System, Veteran's Health Administration, Nashville, TN, USA.
  • Cabrera CP; Division of Rheumatology and Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Wain LV; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Shrestha R; Division of Nephrology, Department of Medicine, Nashville Veteran Affairs Hospital, Nashville, TN, USA.
  • Mautz BS; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.
  • Akwo EA; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Sargurupremraj M; VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
  • Debette S; University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Boehnke M; VA Boston Health Care System, Boston, MA, USA.
  • Scott LJ; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Luan J; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Zhao JH; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Willems SM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Thériault S; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Shah N; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Oldmeadow C; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Almgren P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Li-Gao R; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Verweij N; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Boutin TS; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK.
  • Mangino M; Department of Health Sciences, University of Leicester, Leicester, UK.
  • Ntalla I; National Institute for Health Research, Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
  • Feofanova E; Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA, USA.
  • Surendran P; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN, USA.
  • Cook JP; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Karthikeyan S; University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, Bordeaux, France.
  • Lahrouchi N; University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, Bordeaux, France.
  • Liu C; Department of Neurology, Bordeaux University Hospital, Bordeaux, France.
  • Sepúlveda N; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Richardson TG; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Kraja A; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Nat Genet ; 51(1): 51-62, 2019 01.
Article en En | MEDLINE | ID: mdl-30578418
ABSTRACT
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Etnicidad Tipo de estudio: Risk_factors_studies Límite: Adolescent / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Etnicidad Tipo de estudio: Risk_factors_studies Límite: Adolescent / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos