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Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation.
Balaz, Miroslav; Becker, Anton S; Balazova, Lucia; Straub, Leon; Müller, Julian; Gashi, Gani; Maushart, Claudia Irene; Sun, Wenfei; Dong, Hua; Moser, Caroline; Horvath, Carla; Efthymiou, Vissarion; Rachamin, Yael; Modica, Salvatore; Zellweger, Caroline; Bacanovic, Sara; Stefanicka, Patrik; Varga, Lukas; Ukropcova, Barbara; Profant, Milan; Opitz, Lennart; Amri, Ez-Zoubir; Akula, Murali K; Bergo, Martin; Ukropec, Jozef; Falk, Christian; Zamboni, Nicola; Betz, Matthias Johannes; Burger, Irene A; Wolfrum, Christian.
Afiliación
  • Balaz M; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland.
  • Becker AS; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland; Institute of Diagnostic and Interventional Radiology, University Hospital of Zürich, Zürich, Switzerland; Department of Nuclear Medicine, University Hospital of Zürich, Rämistrasse 100, Zürich 8
  • Balazova L; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland.
  • Straub L; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland.
  • Müller J; Department of Nuclear Medicine, University Hospital of Zürich, Rämistrasse 100, Zürich 8091, Switzerland.
  • Gashi G; Department of Endocrinology, Diabetology, and Metabolism, University Hospital of Basel, Petersgraben 4, Basel 4031, Switzerland.
  • Maushart CI; Department of Endocrinology, Diabetology, and Metabolism, University Hospital of Basel, Petersgraben 4, Basel 4031, Switzerland.
  • Sun W; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland.
  • Dong H; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland.
  • Moser C; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland.
  • Horvath C; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland.
  • Efthymiou V; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland.
  • Rachamin Y; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland.
  • Modica S; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland.
  • Zellweger C; Department of Nuclear Medicine, University Hospital of Zürich, Rämistrasse 100, Zürich 8091, Switzerland.
  • Bacanovic S; Department of Nuclear Medicine, University Hospital of Zürich, Rämistrasse 100, Zürich 8091, Switzerland.
  • Stefanicka P; Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, Bratislava, Slovakia.
  • Varga L; Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, Bratislava, Slovakia; Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia.
  • Ukropcova B; Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia; Institute of Pathological Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
  • Profant M; Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, Bratislava, Slovakia.
  • Opitz L; Functional Genomics Center Zürich, ETH Zürich/University of Zürich, Zürich, Switzerland.
  • Amri EZ; Université Côte d'Azur, CNRS, Inserm, iBV, Nice, France.
  • Akula MK; Sahlgrenska Cancer Center, Department of Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Bergo M; Sahlgrenska Cancer Center, Department of Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.
  • Ukropec J; Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia.
  • Falk C; Department of Medical Data Management, University Hospital of Zürich, Zürich, Switzerland.
  • Zamboni N; Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.
  • Betz MJ; Department of Endocrinology, Diabetology, and Metabolism, University Hospital of Basel, Petersgraben 4, Basel 4031, Switzerland. Electronic address: matthias.betz@usb.ch.
  • Burger IA; Department of Nuclear Medicine, University Hospital of Zürich, Rämistrasse 100, Zürich 8091, Switzerland. Electronic address: irene.burger@usz.ch.
  • Wolfrum C; Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland. Electronic address: christian-wolfrum@ethz.ch.
Cell Metab ; 29(4): 901-916.e8, 2019 04 02.
Article en En | MEDLINE | ID: mdl-30581121
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prenilación de Proteína / Adipocitos Marrones / Proteína Desacopladora 1 / Ácido Mevalónico Límite: Adolescent / Adult / Animals / Humans / Male / Middle aged Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prenilación de Proteína / Adipocitos Marrones / Proteína Desacopladora 1 / Ácido Mevalónico Límite: Adolescent / Adult / Animals / Humans / Male / Middle aged Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos