Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy.

Hitomi, Takefumi; Inouchi, Morito; Takeyama, Hirofumi; Kobayashi, Katsuya; Sultana, Shamima; Inoue, Takeshi; Nakayama, Yuko; Shimotake, Akihiro; Matsuhashi, Masao; Matsumoto, Riki; Chin, Kazuo; Takahashi, Ryosuke; Ikeda, Akio

Hitomi, Takefumi; Inouchi, Morito; Takeyama, Hirofumi; Kobayashi, Katsuya; Sultana, Shamima; Inoue, Takeshi; Nakayama, Yuko; Shimotake, Akihiro; Matsuhashi, Masao; Matsumoto, Riki; Chin, Kazuo; Takahashi, Ryosuke; Ikeda, Akio.

Afiliación

Hitomi T; Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Inouchi M; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Takeyama H; Department of Clinical Laboratory, Kyoto University Hospital, Kyoto, Japan.
Kobayashi K; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sultana S; Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Inoue T; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nakayama Y; Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Shimotake A; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Matsuhashi M; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Matsumoto R; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Chin K; Department of Clinical Laboratory, Kyoto University Hospital, Kyoto, Japan.
Takahashi R; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ikeda A; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Epilepsy Behav Case Rep ; 11: 18-21, 2019.

Article en En | MEDLINE | ID: mdl-30591883

RESUMEN

To clarify the effects of sleep on cortical irritability in benign adult familial myoclonus epilepsy (BAFME), we retrospectively compared epileptiform discharges of electroencephalographies (EEGs) between awake and sleep periods in 5 patients (mean age: 49.6â¯±â¯20.3â¯years). We also analyzed polysomnography (PSG) of 1 patient. Epileptiform discharges were significantly more frequent during the awake period (1.3â¯±â¯1.2/min) than those during light sleep stages (0.02â¯±â¯0.04/min) (Pâ¯<â¯0.05). Regarding PSG analysis, epileptiform discharges were also reduced during all sleep stages compared to those during awake periods. Our study suggests a relative reduction in cortical irritability during sleep in BAFME.

Palabras clave

ADCME, autosomal dominant cortical tremor, myoclonus, and epilepsy; BAFME, benign adult familial myoclonus epilepsy; Benign adult familial myoclonus epilepsy (BAFME); EEG, electroencephalography; EMG, electromyography; Effects of sleep modification on cortical irritability; Epileptiform discharges; FCMTE, familial cortical myoclonic tremor with epilepsy; PSG, polysomnography; REM, rapid eye movement; ULD, Unverricht-Lundborg disease; nCPAP, nasal continuous positive airway pressure

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Epilepsy Behav Case Rep Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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