Quassinoids from seeds of Brucea Javanica and their anticomplement activities.
Nat Prod Res
; 34(8): 1186-1191, 2020 Apr.
Article
en En
| MEDLINE
| ID: mdl-30618292
ABSTRACT
An investigation on seeds of Brucea javanica led to the acquisition of a new quassinoid, 20-hydroxyyadanzigan (1), along with five known quassinoids (2-6). The structure of the new compound was elucidated on the basis of extensive spectral analysis. All of the compounds were assayed for their anticomplement activities through classical and alternative pathways. Compounds 1-6 exhibited potent anticomplement activity with CH50 and AP50 values of 0.032-0.075 mg/mL and 0.061-0.118 mg/mL, respectively. Moreover, the structure-activity relationships of these compounds are discussed.[Formula see text].
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Semillas
/
Proteínas Inactivadoras de Complemento
/
Brucea
/
Cuassinas
Idioma:
En
Revista:
Nat Prod Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
China