[On the road to deciphering the tubulin code: focus on acetylation and detyrosination]. / Déchiffrage du code tubuline - Le voile se lève sur le rôle de l'acétylation et de la détyrosination.
Med Sci (Paris)
; 34(12): 1047-1055, 2018 Dec.
Article
en Fr
| MEDLINE
| ID: mdl-30623774
ABSTRACT
Microtubules are cytoskeletal fibers formed by the assembly of α- and ß-tubulin heterodimers. They contribute to cell morphology, mobility and polarity, as well as to cellular transport processes and cell division. The microtubular network constantly adapts to cellular needs and may be composed of very dynamic or more stable microtubules. To regulate their diverse functions in a spatio-temporal manner, microtubules are subjected to numerous reversible post-translational modifications, which generate the "tubulin code". This review focuses on two modifications characteristic of stable microtubules - acetylation and detyrosination of α-tubulin - and their deregulation in certain pathologies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Acetiltransferasas
/
Tirosina
/
Tubulina (Proteína)
/
Procesamiento Proteico-Postraduccional
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
Fr
Revista:
Med Sci (Paris)
Asunto de la revista:
MEDICINA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia