MicroRNA192 acts as a tumor suppressor in colon cancer and simvastatin activates miR192 to inhibit cancer cell growth.
Mol Med Rep
; 19(3): 1753-1760, 2019 Mar.
Article
en En
| MEDLINE
| ID: mdl-30628692
ABSTRACT
Colon cancer is one of the most common malignant tumors worldwide. Understanding the underlying molecular mechanisms is crucial for the development of therapeutic strategies for the treatment of patients with colon cancer. In the present study, a novel tumor suppressive microRNA, miR192, was demonstrated to be markedly downregulated in colon cancer cells compared with normal colon cells. By overexpressing miR192 in colon cancer HCT116 cells, the results of the present study revealed that miR192 inhibits cell proliferation, migration and invasion. Bioinformatics were used to determine the target gene of miR192 and Rasrelated protein Rab2A (RAB2A) was identified as a downstream target of miR192. Following the determination of the role of the miR192RAB2A pathway in colon cancer, small molecules that may regulate miR192 were screened and the results demonstrated that simvastatin is an activator of miR192. Furthermore, simvastatin upregulated miR192 and inhibited the expression of downstream targets of miR192, which subsequently led to suppressed proliferation, migration and invasion of colon cancer cells. In conclusion, the present study identified a novel colon cancer cell suppressor, as well as a smallmolecule activator of the tumor suppressor miR192, which may represent a therapeutic strategy for the treatment of patients with colon cancer.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias del Colon
/
Simvastatina
/
Proteínas de Unión al GTP rab
/
MicroARNs
/
Carcinogénesis
Límite:
Humans
Idioma:
En
Revista:
Mol Med Rep
Año:
2019
Tipo del documento:
Article