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Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors.
Wu, Yong-Jin; Venables, Brian; Guernon, Jason; Chen, Jie; Sit, Sing-Yuen; Rajamani, Ramkumar; Knox, Ronald J; Matchett, Michele; Pieschl, Rick L; Herrington, James; Bristow, Linda J; Meanwell, Nicholas A; Thompson, Lorin A; Dzierba, Carolyn.
Afiliación
  • Wu YJ; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA. Electronic address: Yong-Jin.wu@bms.com.
  • Venables B; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Guernon J; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Chen J; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Sit SY; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Rajamani R; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Knox RJ; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Matchett M; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Pieschl RL; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Herrington J; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Bristow LJ; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Meanwell NA; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Thompson LA; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
  • Dzierba C; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
Bioorg Med Chem Lett ; 29(4): 659-663, 2019 02 15.
Article en En | MEDLINE | ID: mdl-30638874
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonamidas / Descubrimiento de Drogas / Canal de Sodio Activado por Voltaje NAV1.7 / Indoles Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonamidas / Descubrimiento de Drogas / Canal de Sodio Activado por Voltaje NAV1.7 / Indoles Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido