L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents.

David, J; Gormley, S; McIntosh, A L; Kebede, V; Thuery, G; Varidaki, A; Coffey, E T; Harkin, A

David, J; Gormley, S; McIntosh, A L; Kebede, V; Thuery, G; Varidaki, A; Coffey, E T; Harkin, A.

Afiliación

David J; Trinity College Institute of Neuroscience and School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland.
Gormley S; Trinity College Institute of Neuroscience and School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland.
McIntosh AL; Trinity College Institute of Neuroscience and School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland.
Kebede V; Trinity College Institute of Neuroscience and School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland.
Thuery G; Trinity College Institute of Neuroscience and School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland.
Varidaki A; Turku Centre for Biotechnology, Åbo Akademi University and University of Turku, Turku, Finland.
Coffey ET; Turku Centre for Biotechnology, Åbo Akademi University and University of Turku, Turku, Finland.
Harkin A; Trinity College Institute of Neuroscience and School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland. Electronic address: aharkin@tcd.ie.

Behav Brain Res ; 362: 90-102, 2019 04 19.

Article en En | MEDLINE | ID: mdl-30639510

Asunto(s)

Ácido 2-Aminoadípico/farmacología; Conducta Animal/efectos de los fármacos; Espinas Dendríticas/efectos de los fármacos; Depresión/tratamiento farmacológico; Hipocampo/efectos de los fármacos; Animales; Antidepresivos/farmacología; Astrocitos/efectos de los fármacos; Espinas Dendríticas/patología; Depresión/patología; Trastorno Depresivo/tratamiento farmacológico; Hipocampo/metabolismo; Masculino; Neuronas/efectos de los fármacos; Neuronas/metabolismo; Ratas Wistar

Palabras clave

Astrocytes; Dendritic spine density; Forced swimming test; L-alpha-aminoadipic acid; Pre-limbic cortex; Stress

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Espinas Dendríticas / Depresión / Ácido 2-Aminoadípico / Hipocampo Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2019 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Países Bajos

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