Multiple melanocytic nevi restricted to mycosis fungoides patches in pediatric and young-adult patients. The potential role of local immunosuppression.
Pediatr Dermatol
; 36(2): 232-235, 2019 Mar.
Article
en En
| MEDLINE
| ID: mdl-30656726
ABSTRACT
We described the development of multiple melanocytic nevi within long-standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory-like cytokine profile leading to local immune suppression. The proliferation of nevomelanocytes is regulated by cellular senescence mechanisms mediated by immune system. The immunosuppressive effect of MF infiltrate in conjunction with the systemic effect of treatments may play a specific role in the nevomelanogenesis of the patients herein described.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
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Terapia de Inmunosupresión
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Micosis Fungoide
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Nevo Pigmentado
Límite:
Adult
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Pediatr Dermatol
Año:
2019
Tipo del documento:
Article