Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion.

MacKinney, Anson; Woska, Emily; Spasojevic, Ivan; Batinic-Haberle, Ines; Zennadi, Rahima

MacKinney, Anson; Woska, Emily; Spasojevic, Ivan; Batinic-Haberle, Ines; Zennadi, Rahima.

Afiliación

MacKinney A; Division of Hematology and Duke Comprehensive Sickle Cell Center, Duke University School of Medicine, Durham, NC 27710, United States; Departments of Medicine, Duke University School of Medicine, Durham, NC 27710, United States.
Woska E; Division of Hematology and Duke Comprehensive Sickle Cell Center, Duke University School of Medicine, Durham, NC 27710, United States; Departments of Medicine, Duke University School of Medicine, Durham, NC 27710, United States.
Spasojevic I; Duke Cancer Institute, Pharmaceutical Research Shared Resource, PK/PD Core Laboratory, Duke University School of Medicine, Durham, NC 27710, United States; Departments of Medicine, Duke University School of Medicine, Durham, NC 27710, United States.
Batinic-Haberle I; Departments of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, United States.
Zennadi R; Division of Hematology and Duke Comprehensive Sickle Cell Center, Duke University School of Medicine, Durham, NC 27710, United States; Departments of Medicine, Duke University School of Medicine, Durham, NC 27710, United States. Electronic address: zenna001@mc.duke.edu.

Redox Biol ; 25: 101097, 2019 07.

Article en En | MEDLINE | ID: mdl-30661992

Asunto(s)

Anemia de Células Falciformes/enzimología; Eritrocitos/enzimología; NADPH Oxidasas/metabolismo; Oxígeno/farmacología; Enfermedades Vasculares/sangre; Enfermedades Vasculares/patología; Anemia de Células Falciformes/patología; Adhesión Celular/efectos de los fármacos; Moléculas de Adhesión Celular/metabolismo; Hipoxia de la Célula/efectos de los fármacos; Células Endoteliales/efectos de los fármacos; Células Endoteliales/patología; Activación Enzimática/efectos de los fármacos; Quinasas MAP Reguladas por Señal Extracelular/metabolismo; Retroalimentación Fisiológica; Quinasa 2 del Receptor Acoplado a Proteína-G/metabolismo; Humanos; Nitrosación; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos

Palabras clave

Adhesion; Extracellular signal-regulated kinase-1/2 (ERK1/2); G protein-coupled receptor kinase 2 (GRK2); Hypoxia/reoxygenation; Manganese (Mn) porphyrins; NADPH oxidases; Sickle red blood cell

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Enfermedades Vasculares / NADPH Oxidasas / Eritrocitos / Anemia de Células Falciformes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Redox Biol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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