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Double-Modified Glycopolymers from Thiolactones to Modulate Lectin Selectivity and Affinity.
Wilkins, Laura E; Badi, Nezha; Du Prez, Filip; Gibson, Matthew I.
Afiliación
  • Wilkins LE; Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
  • Badi N; Polymer Chemistry Research Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281 S4-bis, Ghent B-9000, Belgium.
  • Du Prez F; Polymer Chemistry Research Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281 S4-bis, Ghent B-9000, Belgium.
  • Gibson MI; Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
ACS Macro Lett ; 7(12): 1498-1502, 2018 Dec 18.
Article en En | MEDLINE | ID: mdl-30662815
Multivalent glycomaterials show high affinity toward lectins but are often nonselective as they lack the precise 3-D presentation found in native glycans. Here, thiolactone chemistry is exploited to enable the synthesis of glycopolymers with both a primary binding (galactose) and a variable secondary binding unit in close proximity to each other on the linker. These polymers are used to target the Cholera toxin B subunit, CTxB, inspired by its native branched glycan target, GM-1. The secondary, nonbinding unit was shown to dramatically modulate affinity and selectivity toward the Cholera toxin. These increasingly complex glycopolymers, assembled using accessible chemistry, can help breach the synthetic/biological divide to obtain future glycomimetics.

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Macro Lett Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Macro Lett Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos