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Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia.
Bygrave, Alexei M; Masiulis, Simonas; Kullmann, Dimitri M; Bannerman, David M; Kätzel, Dennis.
Afiliación
  • Bygrave AM; Department of Experimental Psychology, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
  • Masiulis S; Department of Experimental Psychology, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
  • Kullmann DM; Institute of Neurology, University College London, London, United Kingdom.
  • Bannerman DM; Department of Experimental Psychology, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
  • Kätzel D; Department of Experimental Psychology, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Front Behav Neurosci ; 12: 332, 2018.
Article en En | MEDLINE | ID: mdl-30687034
ABSTRACT
Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cognitive symptom domains of schizophrenia in a mouse line modeling NMDA-receptor (NMDAR) hypofunction in forebrain inhibitory interneurons (Grin1 ΔPpp1r2 ). We find that Grin1 ΔPpp1r2 mice, when group-housed in highly enriched cages, appear largely normal across a wide range of schizophrenia-related behavioral tests. However, they display various short-term memory deficits when exposed to minimal enrichment. This demonstrates that the interaction between risk genes causing NMDA-receptor hypofunction and environmental risk factors may negatively impact cognition later in life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Behav Neurosci Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Behav Neurosci Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido