Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Genes With Euchromatic Promoters in Mice.

Grindheim, Jessica Mae; Nicetto, Dario; Donahue, Greg; Zaret, Kenneth S

Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Genes With Euchromatic Promoters in Mice.

Grindheim, Jessica Mae; Nicetto, Dario; Donahue, Greg; Zaret, Kenneth S.

Afiliación

Grindheim JM; Institute for Regenerative Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Penn Epigenetics Institute, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Department of Cell and Developmental Bi
Nicetto D; Institute for Regenerative Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Penn Epigenetics Institute, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Department of Cell and Developmental Bi
Donahue G; Institute for Regenerative Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Penn Epigenetics Institute, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Department of Cell and Developmental Bi
Zaret KS; Institute for Regenerative Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Penn Epigenetics Institute, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Department of Cell and Developmental Bi

Gastroenterology ; 156(6): 1834-1848, 2019 05.

Article en En | MEDLINE | ID: mdl-30689973

Asunto(s)

Diferenciación Celular/genética; Proteína Potenciadora del Homólogo Zeste 2/genética; Represión Epigenética; Regulación de la Expresión Génica/genética; Cirrosis Hepática/genética; Complejo Represivo Polycomb 2/genética; Animales; Proteína Potenciadora del Homólogo Zeste 2/metabolismo; Eucromatina; Femenino; Expresión Génica; Ontología de Genes; Hepatocitos; Histonas/metabolismo; Cirrosis Hepática/patología; Masculino; Metilación; Ratones; Complejo Represivo Polycomb 2/metabolismo; Regiones Promotoras Genéticas; Factores de Tiempo

Palabras clave

Epigenetics; Fibrosis; H3K27me3; Hepatocyte

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Regulación de la Expresión Génica / Complejo Represivo Polycomb 2 / Represión Epigenética / Proteína Potenciadora del Homólogo Zeste 2 / Cirrosis Hepática Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Gastroenterology Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

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