[Biomarkers of Leukemia ~Description of the Practical Use and Operation in the Clinical Laboratory~]-.
Rinsho Byori
; 65(1): 93-99, 2017 01.
Article
en Ja
| MEDLINE
| ID: mdl-30695517
ABSTRACT
Genetic testing of hematological malignancy is-.indispensable to categorize and diagnose leukemia. The quantitation of fusion gene mRNA built up by chromosomal translocation including BCR-ABL1 (major, minor), RUNX1-RUNX1T1, and PML-RARA and detection of the JAK2 (V617F) mutant gene are performed by our- selves in our hospital. Efficient, practical use is necessary because the number of medical technologists is limited and numbers of tests are increasing annually. The detection of leukemic cells is important in hematological tests. In addition, experienced medical technologists can predict the existence of fusion mutant genes. In this report, we introduce our experience regarding the practical use and operation of biomarkers for leukemia. Medical technologists take advantage of peripheral blood tests for screening, such as the complete blood count (CBC), hemogram, fibrin and fibrinogen degradation products (FDP), and the quantitation of fusion gene mRNA, which offers a definitive diagnosis including BCR-ABL1, RUNX1-RUNX1T1, and PML-RARA, and genetic tests are performed efficiently. [Review].
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia
/
Biomarcadores de Tumor
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
Ja
Revista:
Rinsho Byori
Año:
2017
Tipo del documento:
Article