Changes in Apparent Diffusion Coefficient as Surrogate Marker for Changes in Ki-67 Index Due to Neoadjuvant Chemotherapy in Patients with Invasive Breast Cancer.
Acad Radiol
; 26(10): 1352-1357, 2019 10.
Article
en En
| MEDLINE
| ID: mdl-30711409
ABSTRACT
RATIONALE AND OBJECTIVES:
To evaluate possible correlation between changes in apparent diffusion coefficient (ADC) and Ki-67 index as a result of neoadjuvant chemotherapy (NAC) in patients with invasive breast cancer. METHODS AND MATERIALS Between February 2016 and October 2017, 87 patients with breast cancer underwent diffusion-weighted magnetic resonance imaging (bâ¯=â¯0 and 800 sec/mm2) before and after NAC. ADC and tumor diameter before and after NAC were compared to the Ki-67 index determined from biopsy or surgical specimens.RESULTS:
Ki-67 index did not correlate significantly with ADC before NAC (pâ¯=â¯0.862) or afterwards (pâ¯=â¯0.292), nor did it correlate with tumor diameter before (pâ¯=â¯0.545) or afterwards (pâ¯=â¯0.478). However, change in ADC as a result of NAC correlated inversely with change in Ki-67 index (râ¯=â¯-0.326, pâ¯=â¯0.002). The percentage change in Ki-67 index did not correlate with the percentage change in ADC (pâ¯=â¯0.404). Similarly, the change in Ki-67 index or percentage change in that index did not correlate with the change in tumor diameter (pâ¯=â¯0.075) or percentage change in tumor diameter (pâ¯=â¯0.233).CONCLUSION:
Comparison of pre- and post-NAC ADC can be used to estimate the change in Ki-67 index in patients with invasive breast cancer.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
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Antígeno Ki-67
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Terapia Neoadyuvante
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Imagen de Difusión por Resonancia Magnética
Tipo de estudio:
Observational_studies
Límite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Acad Radiol
Asunto de la revista:
RADIOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
China